Clinical Toxicology & Drugs of Misuse

Chair

Loralie J. Langman
Mayo Clinic, USA

Vice-Chair

Souleiman El Balkhi
Limoges, France

Committee Purpose

  • To educate a new generation of toxicologists
  • To provide evidence-based recommendations for CTDOA scientists, clinicians, laboratory and health care personal about drugs of use and misuse and their interactions.
  • To promote the knowledge and understanding of drug analysis, clinical toxicological normal and abnormal values and interpretation of results.
  • To develop communication between scientists and physicians of all disciplines involved in Clinical Toxicology of therapeutics and drugs of misuse.
  • To enhance the collaboration between all the toxicologists belonging to the committee and the members of other committees.
  • To encourage the effective application of CT in all aspects of medicine, with the aim of optimizing clinical therapeutic use, avoid drug adverse reactions or interaction between drugs of use and misuse and maximizing the clinical and economic benefits.
  • To focus on Pharmacogenetics — Immuno-pharmaco-genetics — Personalized medicine.
  • Manuela Neuman is a co-editor of e-news.

Publications in Therapeutic Drug Monitoring Last 2 Years

Small Changes, Big Consequences? Assessment of the Impact of Design Changes in Microsampling Devices. Boffel L, Stove CP. Ther Drug Monit. 2025 Dec 12. doi: 10.1097/FTD.0000000000001422. Online ahead of print. PMID: 41382331 No abstract available.

To Convert or Not to Convert? Official International Association of Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Considerations and Recommendations for Converting Capillary Blood Microsampling Concentrations to Plasma Concentrations. Boffel L, De Baets H, Heughebaert L, Rispens T, Åsberg A, Shipkova M, de Winter BCM, Moes DJAR, de Vries A, Alffenaar JC, Stove CP. Ther Drug Monit. 2026 Feb 1;48(1):1-26. doi: 10.1097/FTD.0000000000001393. Epub 2025 Nov 5. PMID: 41191790

Toward Clinical Implementation of a Volumetric Absorptive Microsampling-Based Method for Dasatinib and Imatinib Therapeutic Drug Monitoring.
Verougstraete N, Mazure D, Stove CP. Ther Drug Monit. 2025 Dec 1;47(6):740-746. doi: 10.1097/FTD.0000000000001387. Epub 2025 Sep 18. PMID: 40965046

Improvements, Challenges, and the Investigation of Two Unknowns in Arsenic Urine Speciation Analysis by HPLC-ICP-MS: From Development to Post-implementation. Smith K, Genesi BT, Boyd JM, Johnson-Davis KL. Ther Drug Monit. 2025 Dec 23;48(2):235-243. doi: 10.1097/FTD.0000000000001412. PMID: 41348096

Broad-Spectrum Drug Screening Positivity Rates in Pediatrics and Adults: The Reference Laboratory Perspective. Shean RC, Johnson-Davis KL. Ther Drug Monit. 2025 Oct 10;48(2):244-251. doi: 10.1097/FTD.0000000000001400. PMID: 41068998

Smith K, Genesi BT, Boyd JM, Johnson-Davis KL. Improvements, Challenges, and the Investigation of Two Unknowns in Arsenic Urine Speciation Analysis by HPLC-ICP-MS: From Development to Post-implementation. Ther Drug Monit. 2026 Apr 1;48(2):235-243. doi: 10.1097/FTD.0000000000001412. Epub 2025 Dec 23. PMID: 41348096; PMCID: PMC12978725.

Shean RC, Johnson-Davis KL. Broad-Spectrum Drug Screening Positivity Rates in Pediatrics and Adults: The Reference Laboratory Perspective. Ther Drug Monit. 2026 Apr 1;48(2):244-251. doi: 10.1097/FTD.0000000000001400. Epub 2025 Oct 10. PMID: 41068998; PMCID: PMC12978719.

Masuda S, Lemaitre F, Barten MJ, Bergan S, Shipkova M, van Gelder T, Vinks S, Wieland E, Bornemann-Kolatzki K, Brunet M, de Winter B, Dieterlen MT, Elens L, Ito T, Johnson-Davis K, Kunicki PK, Lawson R, Lloberas N, Marquet P, Millan O, Mizuno T, Moes DJAR, Noceti O, Oellerich M, Pattanaik S, Pawinski T, Seger C, van Schaik R, Venkataramanan R, Walson P, Woillard JB, Langman LJ. Everolimus Personalized Therapy: Second Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Ther Drug Monit. 2025 Feb 1;47(1):4-31. doi: 10.1097/FTD.0000000000001250. Epub 2024 Sep 25. PMID: 39331837.

Kunz M, Wagmann L, Schuster M, Götzinger F, Andreas Link, Felix Mahfoud. Unveiling Cardiac Complications: A Case of Amisulpride Overdose Leading to Bradycardia, QT-Prolongation, and Torsade de Pointes Tachycardia. Ther Drug Monit. 2025 Mar 5;47(4):462-465. doi: 10.1097/FTD.0000000000001318. PMID: 40643136

Jacobs CM, Wagmann L, Meyer MR. Sample Matrices for Mass Spectrometry-Based Adherence Monitoring: A Systematic Critical Review. Ther Drug Monit. 2024 Feb 1;46(1):6-15. doi: 10.1097/FTD.0000000000001145. PMID: 37798828

Koppen AJ, Mian P, Sturkenboom MGG. A comprehensive overview of the treatment of acute paracetamol overdose. Ther Drug Monit. 2025 Oct 31. doi: 10.1097/FTD.0000000000001403. Online ahead of print. PMID: 41182883.

Kroes, JH, Poortvliet J, Touw DJ, Oortgiesen B, Sturkenboom MGG. Paracetamol half-life declines over time following an acute overdose. Ther Drug Monit. 2025 Sep 24. doi: 10.1097/FTD.0000000000001395. Online ahead of print. PMID: 40990326.

Nazar M, Kootstra-Ros JE, Touw DJ, Sturkenboom MGG. In vitro study of the effects of acetylcysteine on the international normalized ratio over time. Ther Drug Monit. 2025 Jul 14. doi: 10.1097/FTD.0000000000001356. Online ahead of print. PMID: 40663728.

Steenkamp V, Parkar H, Raphiri B, Neuman MG, Dasgupta A. Herbal Remedies in Global Health Care: Classification, Toxicology, and Clinical Management. Ther Drug Monit. 2025;48:210-219 DOI: 10.1097/FTD.0000000000001417 (IF = 2.4) ) [Special issue dedicated to Dr Sunshine]

Verougstraete N, Mazure D, Stove CP. Toward Clinical Implementation of a Volumetric Absorptive Microsampling-Based Method for Dasatinib and Imatinib Therapeutic Drug Monitoring. Ther Drug Monit 2025;47:740-746.

Van Herteryck C, Reyns T, Jager N, Stove V, Verougstraete N. Addressing Analytical Challenges to Improve Laboratory Consistency in Unbound Flucloxacillin Measurement. Ther Drug Monit 2026; online ahead of print (doi: 10.1097/FTD.0000000000001449)

Jousselin E, Griffeuille P, Petit I, Saint-Marcoux F, El Balkhi S, Védrenne N. Detecting the Undetectable: Analytical Strategies for Novel Psychoactive Substances. Ther Drug Monit. 2026 Apr 1;48(2):160-171. doi: 10.1097/FTD.0000000000001431. Epub 2026 Jan 9. PMID: 41508320.

Bressin P, El Balkhi S, El Hamel C, Yardin C, Guigonis V, Saint-Marcoux F, Ponthier L. Pyrethroid Exposure in Premature Newborns: A Pilot Study on Materno-Fetal Transmission and Early Postnatal Evolution. Ther Drug Monit. 2026 Apr 1;48(2):266-275. doi: 10.1097/FTD.0000000000001407. Epub 2025 Oct 31. PMID: 41182891.

El Balkhi S, Franssen EJF. Twenty Years of Evolution in Toxicology Laboratories: Lessons Learned to Face Upcoming Challenges in Health Care and Society. Ther Drug Monit. 2026 Apr 1;48(2):141-148. doi: 10.1097/FTD.0000000000001409. Epub 2025 Nov 13. PMID: 41232029.

El Balkhi S, Machon C. Toxicology of Heavy Metals in Biological Matrices: A Paradigm Shift From Single-Analyte Measurement to Comprehensive Screening. Ther Drug Monit. 2026 Apr 1;48(2):196-209. doi: 10.1097/FTD.0000000000001416. Epub 2025 Dec 8. PMID: 41358615.

Griffeuille P, El Balkhi S, Dulaurent S, Saint-Marcoux F. Probe Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantification of Benzodiazepines. Ther Drug Monit. 2024 Aug 1;46(4):522-529. doi: 10.1097/FTD.0000000000001189. Epub 2024 Mar 18. PMID: 38498915.

Stefan C, Jung B, Zhou J, Franssen EJF, Langman LJ, Fu L. Urine Drug Testing: Service Models and Laboratory Practices to Meet Clinical Care Needs. Ther Drug Monit. 2026 Apr 1;48(2):185-195. doi: 10.1097/FTD.0000000000001428. Epub 2026 Feb 23.PMID: 41729621

Lien TNT, Mohamed SMM, van den Bogaard B, Touw DJ, Franssen EJF. Effects of Plasmapheresis on Serum Lithium Levels in an ICU Patient with Bipolar Disorder: A Case Study. Ther Drug Monit. 2024 Jun 1;46(3):281-284. doi: 10.1097/FTD.0000000000001191. PMID: 38723114.

 

Publication in Compass Last 2 Years

Bennett M. The Illicit Fentanyl Landscape: Trends, Concentrations and Co-Occurrences. Compass, 2026. March; 25(1).

Bennett M. An Alternative Strategy for Detecting Novel Psychoactive Substances in Urine. Compass. 2025 Jun; 24(2).

Steenkamp V. Starting, growing, leading: A scientific journey. COMPASS 2026;25(1) March

Chelsea B Swartchick and Loralie Langman Phosphatidylethanol Measurement: Advantages, Limitations And Future Perspectives. COMPASS 2025;25(41) Dec

Lea Wagmann , Cytotoxicity Testing Of New Psychoactive Substances In Clinical Toxicology COMPASS 2024;23(1) March

Lea Wagmann Award Contribution: In Vitro Biotransformation Of Six Compounds Derived From The Stimulant Prolintane COMPASS 2026;25(soon) June

 

Practice Guidelines/Standards

Hiemke et al.: Consensus Guidelines for TDM in Neuropsychopharmacology: Update 2017, Pharmacopsychiatry 2018; 51: 9-62

Draft consensus document https://myadlm.org/science-and-research/academy-guidance/guidance-document-comments

Loralie J Langman (Chair)
Souleiman El Balkhi (Vice-Chair)
Eric Franssen (Past Chair)
Hans Maurer
Vanessa Steenkamp
Lei Fu
M G G Sturkenboom
Cristiana Stefan
Franck Saint-Marcoux
Manuela Neuman
Ryuji Kato
Lea Wagmann
Guillaume Drevin
Melissa Bennett
Christophe Stove
Kamisha Johnson-Davis
Daan Huntjens
Verougstraete Nick

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