Antimicrobial Therapeutic Drug Monitoring in Critically Ill Adult Patients: A Position Paper

Intensive Care Med. 2020 Jun;46(6):1127-1153
Mohd H Abdul-Aziz, Jan-Willem C Alffenaar, Matteo Bassetti, Hendrik Bracht, George Dimopoulos, Deborah Marriott, Michael N Neely, Jose-Artur Paiva, Federico Pea, Fredrik Sjovall, Jean F Timsit, Andrew A Udy, Sebastian G Wicha, Markus Zeitlinger, Jan J De Waele, Jason A Roberts, Infection Section of European Society of Intensive Care Medicine (ESICM); Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID); Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT); Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC)

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Abstract: This Position Paper aims to review and discuss the available data on therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill adult patients in the intensive care unit (ICU). This Position Paper also provides a practical guide on how TDM can be applied in routine clinical practice to improve therapeutic outcomes in critically ill adult patients.