Immunosuppressive Drugs

Chair

Nuria Lloberas
Barcelona, Spain

Vice-Chair

Nils Tore
Oslo, Norway

Committee Purpose

The global missions of the ISD SC are:

  • To provide evidence-based recommendations for TDM of immunosuppressive agents
  • To promote the knowledge and understanding of immunosuppressive drug analysis and interpretation of results
  • To enhance communication between scientists and physicians of all disciplines involved in TDM of immunosuppressive drugs
  • To encourage the effective application of TDM in transplant medicine, with the aim of optimizing clinical drug use and maximizing the clinical and economic benefits
  • To enhance transversal interactions with other committees
  • 486 publications from members in peer-reviewed journals
  • Special issue in TDM coordinated by Maria Shipkova, February 2025 – Volume 47, Issue 1
    • 15 articles on analytics, alternative matrices, clinical trials…
  • A special issue on toxicology with the collaboration of CTC committee:
    • 5 articles from the committee and a joint editorial “20 years of evolution in toxicology laboratories: lessons from the past to face the upcoming challenge”
  • Contributed one episode to IATDMCT Podcast “Eight Drugs A Week”
    Pharmacogenetics: Here, There and Everywhere with E Cecchin & JJ Swen (Episode 13)
  • Communications in the Singapore IATDMCT congress
  • A pre-congress workshop on AI tools and literature reviews writing (Singapore IATDMCT congress)
  • Two symposia organized for IATDMCT 2025 – Singapore
    • One symposium by the PGx Committee: Prospective implementation of pharmacogenomics in the clinical practice: NGS versus targeted genotyping strategies (Speakers: E Cecchin, A Somogyi, JG Shin)
    • One joint symposium by the PGx–Oncology committees: Integration of pharmacogenetics and Therapeutic Drug Monitoring (TDM) in Clinical Practice (Chairs: C Chowbay, N Hellyer, C Largiadèr, S Ackland)

 
2023: Everolimus Personalized Therapy: Second Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.
Masuda S, Lemaitre F, Barten MJ, Bergan S, Shipkova M, van Gelder T, Vinks S, Wieland E, Bornemann-Kolatzki K, Brunet M, de Winter B, Dieterlen MT, Elens L, Ito T, Johnson-Davis K, Kunicki PK, Lawson R, Lloberas N, Marquet P, Milan Q, Mizuno T, Moes DJAR, Noceti O, Oellerich M, Pattanaik S, Pawinski T, Seger C, van Schaik R, Venkataramanan R, Walson P, Woillard JB, Langman LJ. Ther Drug Monit. 2025 Feb 1;47(1):43–71. doi: 10.1097/FTD.0000000000001250. Review.

2023: Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19. Lemaitre F, Budde K, Van Gelder T, Bergan S, Lawson R, Noceti O, Venkataramanan R, Elens L, Moes DJAR, Hesselink DA, Pawinski T, Johnson-Davis KL, De Winter BCM, Pattanaik S, Brunet M, Masuda S, Langman LJ.., Ther Drug Monit. 2023 Apr 1;45(2):191-199

2023: TDM is Alive and Kicking! Lemaitre F, Hesselink DA. Ther Drug Monit. 2023 Feb 1;45(1):3-5.

2025

 
The strange case for therapeutic drug monitoring absence in phase III trials
Florian Lemaitre, Sébastien Lalanne and Marie-Clémence Verdier
 
Changes in the pharmacokinetic profile of mycophenolate mofetil and tacrolimus in transplant patients undergoing bowel surgery: insights from a case report.
Nuria Montero and Nuria Lloberas
 

2024

 
Closing the Ethnicity Gap in Pharmacogenomics: Insights from Tacrolimus Pharmacokinetics and the Impact of CYP3A5*6
Amar Levens, Dirk Jan Moes and Jesse Swen

2025

 
23rd Congress, September 21-24, Singapore

  • Communications in the Singapore IATDMCT congress
  • A pre-congress workshop on AI tools and literature reviews writing (Singapore IATDMCT congress)
  • Two symposia organized for IATDMCT 2025 – Singapore
    • One symposium by the PGx Committee: Prospective implementation of pharmacogenomics in the clinical practice: NGS versus targeted genotyping strategies (Speakers: E Cecchin, A Somogyi, JG Shin)
    • One joint symposium by the PGx–Oncology committees: Integration of pharmacogenetics and Therapeutic Drug Monitoring (TDM) in Clinical Practice (Chairs: C Chowbay, N Hellyer, C Largiadèr, S Ackland)

 

2025

 
2025 European Regional Meeting of IATDMCT, November 28-29, 2025, Leiden, Netherlands
TDM in transplantation (Chairs: Nuria Lloberas, Anders Åsberg)

  • Florian Lemaitre: AUC predictions with finger-prick samples
  • Pharmacomicrobiomics and immunosuppressant TDM – future possibilities
  • How to use dosing tools in Tac dosing

2026

 
Participation with the with the Spanish Transplant Society (SET) to organize a symposium with focus on immunosuppressive drugs in 2026.
 

2025

 
Transplant Care. Madrid October 3, 4th
Immunosuppressive scientific coordinator: Nuria Lloberas
IATDMCT speakers: The predictive value of pharmacogenetic biomarkers in the management of immunosuppression in clinical practice. Laure Elens
 
Update in Personalized Immunosuppression (and IATDMCT). Barcelona, May 16, 2025. Hospital Universitari de Bellvitge
Coordination: Nuria Lloberas
IATDMCT speakers:

  • Dry blood samples in clinical practice. Florian Lemaitre
  • Getting Tacrolimus Dosing Right. Teun van Gelder
  • Therapeutic Drug monitoring in clinical practice. Transplant physicians and pharmacologist interaction. E.Melilli and N Lloberas

Nuria Lloberas (Chair)
Nils Tore Vethe (Vice-Chair)
Markus J. Barten
Stein Bergan
Mercè Brunet
Klemens Budde
Muja Bulatovic-Calasan
Uwe Christians
Brenda de Winter
Maurit Derotte
Laure Elens
Vincent Haufroid
Dennis Hesselink
Kamisha Johnson-Davis
Arkadiusz Kocur
Pawel K. Kunicki
Loralie J. Langman
Ronald Lawson
Florian Lemaitre
Pierre Marquet
Satohiro Masuda
Binu Susan Mathew
Soufian Meziyerh
Olga Millan
Michael Milone
Dirk-Jan Moes
Tomoyuki Mizuno
Ofelia Noceti
Michael Oellerich
Smita Pattanaik
Tomasz Pawinski
Christoph Seger
Natalia Riva
Les Shaw
Maria Shipkova
Christine Staatz
Judith Taibon
Teun van Gelder
Ron van Schaik
Raman Venkataraman
Sander Vinks
Pierre Wallemacq
Ping Wang
Eberhard Wieland
Naoki Yoshikawa

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