Clinical Toxicology & Drugs of Misuse

Chair

Eric Franssen
Utrecht, Netherlands

Vice-Chair

Loralie J. Langman
Mayo Clinic, USA

Committee Purpose

  • To educate a new generation of toxicologists
  • To provide evidence-based recommendations for CTDOA scientists, clinicians, laboratory and health care personal about drugs of use and misuse and their interactions.
  • To promote the knowledge and understanding of drug analysis, clinical toxicological normal and abnormal values and interpretation of results.
  • To develop communication between scientists and physicians of all disciplines involved in Clinical Toxicology of therapeutics and drugs of misuse.
  • To enhance the collaboration between all the toxicologists belonging to the committee and the members of other committees.
  • To encourage the effective application of CT in all aspects of medicine, with the aim of optimizing clinical therapeutic use, avoid drug adverse reactions or interaction between drugs of use and misuse and maximizing the clinical and economic benefits.
  • To focus on Pharmacogenetics — Immuno-pharmaco-genetics — Personalized medicine.
  • Manuela Neuman is a co-editor of e-news.

Publications in Therapeutic Drug Monitoring

Jacobs CM, Wagmann L, Meyer MR. Sample Matrices for Mass Spectrometry-Based Adherence Monitoring: A Systematic Critical Review. Ther Drug Monit. 2024 Feb 1;46(1):6-15. doi: 10.1097/FTD.0000000000001145. Epub 2023 Oct 5. PMID: 37798828.

Kweekel DM, McCune JS, Punt AM, van Luin M, Franssen EJF. Busulfan Interlaboratory Proficiency Testing Program Revealed Worldwide Errors in Drug Quantitation and Dose Recommendations. Ther Drug Monit. 2023 May 12. doi: 10.1097/FTD.0000000000001107. Epub ahead of print. PMID: 37199431.

Lien TNT, Mohamed SMM, van den Bogaard B, Touw DJ, Franssen EJF. Effects of Plasmapheresis on Serum Lithium Levels in an ICU Patient with Bipolar Disorder: A Case Study. Ther Drug Monit. 2024 Jun 1;46(3):281-284. doi: 10.1097/FTD.0000000000001191. PMID: 38723114.

Smits TA, Gresnigt FMJ, van Groen BD, Franssen EJF, et al. Prospective Investigation of the Performance of 2 Gamma-Hydroxybutyric Acid Tests: DrugCheck GHB Single Test and Viva-E GHB Immunoassay. Ther Drug Monit. 2020 Feb;42(1):139-145. doi: 10.1097/FTD.0000000000000677.

Märtson A-G, Touw D, et al. Ganciclovir Therapeutic Drug Monitoring: A Case Series. Therapeutic Drug Monitoring. 2019 Apr 1;41(2):107-110. https://doi.org/10.1097/FTD.0000000000000598.

Daskapan A, Tran QTD, Cattaneo D, Gervasoni C, Resnati C, Stienstra Y, Touw DJ, et al. Darunavir population pharmacokinetic model based on HIV outpatient data. Therapeutic Drug Monitoring. 2019;41(1):59-65. https://doi.org/10.1097/FTD.0000000000000576.

Colman S, Stove V, De Waele JJ, Verstraete AG. Measuring Unbound Versus Total Piperacillin Concentrations in Plasma of Critically Ill Patients: Methodological Issues and Relevance. Ther Drug Monit. 2019;41(3):325-330. doi: 10.1097/FTD.0000000000000602.

Neuman MG. Biomarkers of Drug-Induced Liver Toxicity.Therapeutic Drug Monitoring. 2019 – Volume 41 – 2 – p 227–234 doi: 10.1097/FTD.0000000000000610.

Contrucci RR, Brunt TM, Inan F, Franssen EJF, Hondebrink L Synthetic Cathinones and Their Potential Interactions with Prescription Drugs. Ther Drug Monit. 2020 Feb;42(1):75-82. doi: 10.1097/FTD.0000000000000682.

Smy L, Sadler AJ, McMillin GA. Evaluation of imatinib concentrations in samples submitted for BCR-ABL1 or imatinib testing – evidence to support therapeutic drug monitoring for dose optimization? Ther Drug Monit. 2020 May 6. Online ahead of print.

Neuman MG. Biomarkers of Drug-Induced Liver Toxicity. Therapeutic Drug Monitoring. 2019 – Volume 41 – Issue 2 – p 227–234 doi: 10.1097/FTD.0000000000000610.

Bolhuis MS, Akkerman OW, Sturkenboom MG, de Lange WC, van der Werf TS, Touw DJ, Alffenaar JW. Different underlying mechanism might explain the absence of a significant difference in AUC of linezolid for different ABCB1 genotypes. Ther Drug Monit. 2019 Apr;41(2):253-254. doi: 10/1097 (IF2018 2.047).

Oude Munnink TH, van der Meer A, de Haan JJ, Touw DJ, van Kruchten M. Grand Round: Reversible impaired methotrexate clearance after platinum-based chemotherapy for osteosarcoma. Therapeutic Drug Monitoring. 2019 https://doi.org/10.1097/FTD.0000000000000662.

Zuur MA, Veenhof H, Aleksa A, Boveneind-Vrubleuskaya NV, Darmawan E, Hasnain MG et al Touw DJ,. Quality Assessment of Dried Blood Spots from Tuberculosis Patients from Four Countries. Therapeutic Drug Monitoring. 2019 June 4, https://doi.org/10.1097/FTD.0000000000000659.

Capiau S, Veenhof H, Koster R, Bergqvist Y, Boettcher M, Halmingh O et al Touw DJ,. Official International Association for Therapeutic Drug Monitoring and Toxicology guideline: Development and Validation of Dried Blood Spot-based Methods for Therapeutic Drug Monitoring. Therapeutic Drug Monitoring. 2019 Aug;41:409-430. https://doi.org/10.1097/FTD.0000000000000643.

 

Publication in Compass

Is Gabapentin (Neurontin) Misuse on your radar? Kamisha L. Johnson-Davis. University of Utah,Utah, USA

Alcohol, Nutrition, Microbiota and Liver Damage. Manuela G. Neuman. In Vitro Drug Safety and Biotechnology, University of Toronto, Toronto, Canada

The Poisoned Patient: How to Communicate with Clinicians and Guide Further Testing- Amitava Desgupta, University of Huston, Texas, USA

Clinical Toxicology Assessment in Alcohol and Drug-induced Liver Injury in Haemochromatosis. Manuela G. Neuman, In Vitro Drug Safety and Biotechnology, University of Toronto, Toronto, Canada

 

Practice Guidelines/Standards

Hiemke et al.: Consensus Guidelines for TDM in Neuropsychopharmacology: Update 2017, Pharmacopsychiatry 2018; 51: 9-62

Draft consensus document https://myadlm.org/science-and-research/academy-guidance/guidance-document-comments

2022 – Prague
2021 – Virtual

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