Anti-Infective Drugs

Summary of 2025 Activities

• Education activities outcomes: Webinars
  • Optimizing Prescription in LMIC based on Therapeutic Drug Monitoring and PKPD, 03-12-2024
  • Webinar: Controversies in TDM of antifungals, together with ISAP and EPASG, 17-02-2025
  • Webinar on patient cases 24 of June, together with ISAP and EPASG
• Contributions to Compass
  • Maaike and Thi in 2025 (2x)
• Publications:
  • Status of current committee-led submissions:
    • Indy: What is known about TDM for established drugs in LMICs manuscript – steadily working through the process, with input from Immunosuppressant and RAPS reps. Ongoing
    • Andre/Tim: How to perform TDM in patients undergoing continuous renal replacement therapy – submitted to CMI, revised manuscript, TDM will have an executive summary
    • Pieter: TDM of antibiotics in children: A Systematic Review – Full text screening complete –extra people needed (extra info from Pieter: first new time lines for the existing members, will be continued)
    • IBLICS: manuscript has been completed

Scientific Contributions

2022

 
Reuter SE, Stocker SL, Alffenaar JC, Baldelli S, Cattaneo D, Jones G, Koch BCP, Kocic D, Mathew SK, Molinaro M, Neely M, Sandaradura I, Marriott DJE. Optimal Practice for Vancomycin Therapeutic Drug Monitoring: Position Statement From the Anti-infectives Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Ther Drug Monit. 2022 Feb 1;44(1):121-132. doi: 10.1097/FTD.0000000000000944. PMID: 34882107.
 
Kim HY, Baldelli S, Märtson AG, Stocker S, Alffenaar JW, Cattaneo D, Marriott DJE. Therapeutic Drug Monitoring of the Echinocandin Antifungal Agents: Is There a Role in Clinical Practice? A Position Statement of the Anti-Infective Drugs Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Ther Drug Monit. 2022 Feb 1;44(1):198-214. doi: 10.1097/FTD.0000000000000931. PMID: 34654030.
 

2021

 
Roberts JA, Joynt GM, Lee A, Choi G, Bellomo R, Kanji S, Mudaliar MY, Peake SL, Stephens D, Taccone FS, Ulldemolins M, Valkonen MM, Agbeve J, Baptista JP, Bekos V, Boidin C, Brinkmann A, Buizen L, Castro P, Cole CL, Creteur J, De Waele JJ, Deans R, Eastwood GM, Escobar L, Gomersall C, Gresham R, Jamal JA, Kluge S, König C, Koulouras VP, Lassig-Smith M, Laterre PF, Lei K, Leung P, Lefrant JY, Llauradó-Serra M, Martin-Loeches I, Mat Nor MB, Ostermann M, Parker SL, Rello J, Roberts DM, Roberts MS, Richards B, Rodríguez A, Roehr AC, Roger C, Seoane L, Sinnollareddy M, Sousa E, Soy D, Spring A, Starr T, Thomas J, Turnidge J, Wallis SC, Williams T, Wittebole X, Zikou XT, Paul SK, Lipman J; SMARRT Study Collaborators and the ANZICS Clinical Trials Group. The Effect of Renal Replacement Therapy and Antibiotic Dose on Antibiotic Concentrations in Critically Ill Patients: Data From the Multinational Sampling Antibiotics in Renal Replacement Therapy Study. Clin Infect Dis. 2021 Apr 26;72(8):1369-1378. doi: 10.1093/cid/ciaa224. PMID: 32150603.
 

2020

 
Abdul-Aziz MH, Alffenaar JC, Bassetti M, Bracht H, Dimopoulos G, Marriott D, Neely MN, Paiva JA, Pea F, Sjovall F, Timsit JF, Udy AA, Wicha SG, Zeitlinger M, De Waele JJ, Roberts JA. Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#. Intensive Care Med 46, 1127–1153 (2020). https://doi.org/10.1007/s00134-020-06050-1
Infection Section of European Society of Intensive Care Medicine (ESICM)
Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT)
Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC)
 
Märtson AG, Sturkenboom MGG, Stojanova J, Cattaneo D, Hope W, Marriott D, Patanwala AE, Peloquin CA, Wicha SG, van der Werf TS, Tängdén T, Roberts JA, Neely MN, Alffenaar JC. How to design a study to evaluate therapeutic drug monitoring in infectious diseases? Clin Microbiol Infect. 2020 Aug;26(8):1008-1016. doi: 10.1016/j.cmi.2020.03.008. Epub 2020 Mar 21. PMID: 32205294.
 
Cattaneo D, Corona A, De Rosa FG, Gervasoni C, Kocic D, Marriott DJ. The management of anti-infective agents in intensive care units: the potential role of a ‘fast’ pharmacology. Expert Rev Clin Pharmacol. 2020 Apr;13(4):355-366. doi: 10.1080/17512433.2020.1759413. Epub 2020 May 4. PMID: 32320302.
 
Rao GG, Konicki R, Cattaneo D, Alffenaar JW, Marriott DJE, Neely M; IATDMCT Antimicrobial Scientific Committee. Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics. Ther Drug Monit. 2020 Feb;42(1):83-92. doi: 10.1097/FTD.0000000000000710. PMID: 31652190.
 
Cattaneo D, Baldelli S, Cozzi V, Clementi E, Marriott DJE, Gervasoni C; IATDMCT Anti-Infective Committee. Impact of Therapeutic Drug Monitoring of Antiretroviral Drugs in Routine Clinical Management of People Living With HIV: A Narrative Review. Ther Drug Monit. 2020 Feb;42(1):64-74. doi: 10.1097/FTD.0000000000000684. PMID: 31393332.
 
Kim HY, Märtson AG, Dreesen E, Spriet I, Wicha SG, McLachlan AJ, Alffenaar JW. Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review. Front Pharmacol. 2020 Jun 12;11:894. doi: 10.3389/fphar.2020.00894. PMID: 32595511; PMCID: PMC7304296.

2025

 
23rd Congress, September 21-24, Singapore

• Optimizing TB Treatment: Innovations, Challenges, and the Future of Therapeutic Drug Monitoring (joint submission with RAPS)
• Is there a role of TDM for long-acting formulations? (joint submission with ACCP)
• Target Concentrations, Time to Reach Target, Days in Target: Therapeutic Target Parameters (joint submission with RAPS)
• Immunosuppression and infection: monitoring the myth of Janus (joint submission with immunosuppressive committee)
• Dangerous liaisons: an interactive navigation into the antifungals DDI risk
• Mastering TDM studies in Infectious Diseases: Key Insights and Example Trials (workshop)

2024

 
22nd Congress, September 15-18, Banff

• The mysteries of target site concentrations of antibiotics in hard to reach infections: an evolving application of TDM?
  • TDM of long-acting antibiotics for long-term use – Milo Gatti, Italy
  • Stability issues and potential role of TDM for outpatient parenteral antibiotic therapies – Birgit Koch, Netherlands
  • Deciphering and quantifying the penetration of antibiotics in the tissues – Iris K. Minichmayr, Austria
  • Using saliva as an alternative matrix to conduct TDM of antibiotics – Thi Nguyen, Australia

• Dish of the Day
  • Fluconazole – the last azole to optimize? – Isabel Spriet, Belgium
  • Navigating the beta-lactam therapeutic window – Rekha Pai Mangalore, Australia
  • Catching the Culprit: Benzylpenicillin Neurotoxicity Confirmed by TDM in a Critically Ill Patient With CVVH – Maaike Sikma, Netherlands
  • Vancomycin dosage optimization for pediatric patients with special disease conditions – Yuko Shimamoto, Japan
  • Non-renal augmented clearance of linezolid – Jana Stojanova, Australia

• Children are not small adults: paving the road to PK/PD dose optimization of anti-infectives in children
  • Precision dosing of anti-infectives in children – big solution for small people? – Pieter De Cock, Belgium
  • Use of physiologically-based pharmacokinetic modelling for dose optimization of antibiotics in children – Samuel Dubinsky, Canada
  • Implementing model-informed precision dosing of antibiotics at Cincinnati Children’s Hospital Medical Center – Sonya Tang Girdwood, USA
  • Hybrid use of machine learning and population PK/PD to optimize anti-infectives dosing in children – Wei Zhao, China

• Breakfast Roundtable
  • Use of the hollow fiber infection model to generate PK-PD targets in humans (Joint with PMx Committee) – Michael Neely, USA

2023

 
21st Congress, September 24-27, Oslo

• Anti-infectives TDM studies and endpoints
  • Lessons Learned, most promising drugs to study – Birgit Koch
  • Biomarkers – Indy Sandaradura
  • Which endpoint to choose – Michael Neely
  • TDM in countries with other resources, focus on costs – Joao Paulo Marochi Telles

2022

 
20th Congress, September 18-21, Prague

• TDM in the management of infections of implantable devices
  • Infections of implanted cardiac devices – Deborah Marriott
  • Infections of orthopedic protheses – Philip Drennan
  • Relevance of plasma concentrations to biofilm exposure – Indy Sandaradura
• Antibiotics
  • Expression of circulating microRNAs in septic patients treated with nephrotoxic antibiotic agents – Nadezda Petejova
  • Paediatric cystic fibrosis patients as a special population benefiting from therapeutic drug monitoring guided medicine dosing: recent advances including new therapeutic options, life quality and expectancy – Hundie Tesfaye
  • Nephrotoxicity of vancomycine after implementation of higher therapeutic range – Blanka Koristkova

2021

 
19th Congress, September 19-22, Rome

• Infection site measurement of anti-microbial agents: unnecessary, a luxury or essential?
  • Bone and joint infections – Birgit Koch
  • Lungs and pleural space – Federico Pea
  • The role of microdialysis – Markus Zeitlinger

2025

Augmented renal clearance
Maaike Sikma
 
Can we use saliva to personalise our medicines?
Thi Nguyen
 

2023

Who, What, When, Where, How, Why of TDM of linezolid
Cindy Lau, Deborah Marriott, Jonathan Penm, Jan-Willem Alffenaar
 

2022

TDM PRACTICES IN VIETNAM
Anh Xuong Ha, Anh Thi Nguyen
 

2021

Therapeutic drug monitoring of echinocandins. Has the time come?
Deborah Marriott
 
Potential risks of complementary alternative medicines in people living with HIV: the experience at the GAP Clinic
Dario Cattaneo
 
 

• ESCMID (EPASG)
• ESICM
• ISAP
• PAGANZ

Birgit Koch (Chair)
João Paulo Marochi Telles (Vice-Chair)
Johannes Alffenaar
Sara Baldelli
Gustaf Beijer
Sana Boujaafar
Roger Bruggemann
Dario Cattaneo
Paul Chin
Pieter De Cock
Samuel Dubinsky
Erik Eliasson
Joy Gibson
Sonja Girdwood
Rhodes Hambrick
Grace Mary John
Bejamin Kably
Tod Kippin
Danijela Kocic
Toni Lai
Florian Lemaitre
Rafael Linden
Silva Lorenzo
Debbie Marriott
Anne Grete Märtson
Sumith Mathew
Iris Minichmayr
Carsten Mueller
Michael Neely
Thi Nguyen
Rekha Pai Mangalore
Gauri Rao
Stephanie Reuter Lange
Indy Sandaradura
Maaike Sikma
Tim Smeets
Isabel Spriet
Sophie Stocker
Jana Stojanova
Veronique Stove
Esther Uijtendaal
Andre Wieringa
Yoshiki Yamamoto
Saskia Zieck