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ChairNúria Padullés-Zamora |
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Vice-ChairMurray Barclay |
Biologic therapy has revolutionized the treatment of immune mediated inflammatory diseases (IMID), cancer and infectious diseases. However, there is a considerable variation in clinical response to biologic therapy. Primary non-response and loss of therapeutic response to biologics have been attributed to pharmacokinetics (e.g. inadequate trough concentrations) and inflammatory processes (mechanistic failure). In addition, this lack or loss of response may originate from several little-known epigenetic mechanisms. Factors that influence the pharmacokinetics of a biologic should be taken into account (antidrug antibodies, serum albumin, serum levels of C-reactive protein, disease mediated clearance, body weight, and gender among others). Hence, to optimize the efficacy of biologic treatment, there is a need to implement personalized medicine in IMID and oncology. This can be guided by therapeutic drug monitoring (TDM).
The TDM of Biologics Scientific Committee was officially installed in the 2019 IATDMCT Congress. The aims of the committee are:
Contributions to COMPASS 2019:
December 2019: A NEW SCIENTIFIC COMMITTEE HAS BEEN CREATED WITHIN IATDMCT. THE COMMITTEE IS DEDICATED TO PROMOTING THE USE OF THERAPEUTIC DRUG MONITORING OF BIOLOGICS. By Núria Padullés-Zamora, Department of Pharmacy, Hospital Universitari de Bellvitge-HUB. Pharmacotherapy, Pharmacogenetics and Pharmaceutical Technology Program, Institut d’Investigació Biomèdica de Bellvitge-IDIBELL. Barcelona, Spain And Murray Barclay, Gastroenterologist and Clinical Pharmacologist, Christchurch Hospital, Christchurch and Clinical Professor, University of Otago, New Zealand; On behalf of the TDM of Biologics Committee.
Participation in Symposiums and workshops:
Contributions to the scientific program of 17th IATDMCT Congress, Brazil 2019. Proposals for: symposiums.