International Association of
Therapeutic Drug Monitoring and Clinical Toxicology
Fostering education, research and practice in TDM and CT

Young Scientist Abstracts

2016

A Nonparametric Pharmacokinetic Approach to Determine the Optimal Dosing Regimen for 30-Minute and 3-Hour Meropenem Infusions in Critically Ill Patients.
https://www.ncbi.nlm.nih.gov/pubmed/27454665

Mathew SK, Mathew BS, Neely MN, Naik GS, Prabha R, Jacob GG, K S, Fleming DH.

Ther Drug Monit. 2016 Oct;38(5):593-9.

Challenges concerning new psychoactive substance detection in oral fluid
http://www.sciencedirect.com/science/article/pii/S2352007816302293

Wille SM, Eliaerts J, Di Fazio V, Samyn N.

Toxac doi: 10.1016/j.toxac.2016.12.004

New psychoactive substances in a drugged driving population: Preliminary results.
http://www.em-consulte.com/article/1098692/new-psychoactive-substances-in-a-drugged-driving-p

Nachon-Phanithavong M., Wille SM, Richeval C.,Di Fazio V., Samyn N., Humbert L., Gaulier JM, Allorge D.

Toxac doi : 10.1016/j.toxac.2016.12.002

Determination of Antidepressants in Hair via UHPLC-MS/MS as a Complementary Informative Tool for Clinical and Forensic Toxicological Assessments.
https://www.ncbi.nlm.nih.gov/pubmed/27851687

Ramírez Fernández Mdel M, Wille SM, Hill V, Samyn N.

Ther Drug Monit 2016 38 (6): 751-760., PMID:27851687

2015

LC-MS/MS method for determination of teriflunomide, over a 40,000-fold dynamic range using overlapping calibrators
http://www.ncbi.nlm.nih.gov/pubmed/25525756

Rule GS, Rockwood AL, Johnson-Davis KL

Ther Drug Monit. 2015 Aug;37(4):472-8.

A hybrid approach to urine drug testing using high-resolution mass spectrometry and select immunoassays.
http://www.ncbi.nlm.nih.gov/pubmed/25596249

McMillin GA, Marin SJ, Johnson-Davis KL, Lawlor BG, Strathmann FG.

Am J Clin Pathol. 2015 Feb;143(2):234-40.

Everolimus method comparison between Waters MassTrak™ Immunosuppressants XE (IUO) kit and an in-house laboratory developed LC-MS/MS method in renal transplant patients.
http://www.ncbi.nlm.nih.gov/pubmed/25696007

Johnson-Davis KL, Juenke JM, Thomas RL, Bradshaw T.

Ann Clin Lab Sci. 2015 Winter;45(1):27-31.

Ethyl Glucuronide Positivity Rate in a Pain Management Population.
http://www.ncbi.nlm.nih.gov/pubmed/26324207

Johnson-Davis KL, Slawson MH.

J Anal Toxicol. 2015 Nov;39(9):686-90.

One Hundred False-Positive Amphetamine Specimens Characterized by Liquid Chromatography Time-of-Flight Mass Spectrometry.
http://www.ncbi.nlm.nih.gov/pubmed/26342055

Marin SJ, Doyle K, Chang A, Concheiro-Guisan M, Huestis MA, Johnson-Davis KL

J Anal Toxicol. 2016 Jan-Feb;40(1):37-42. Epub 2015 Sep 4.

A Retrospective Analysis of Urine Drugs of Abuse Immunoassay True Positive Rates at a National Reference Laboratory.
http://www.ncbi.nlm.nih.gov/pubmed/26668238

Johnson-Davis KL, Sadler AJ, Genzen JR

J Anal Toxicol. 2016 Mar;40(2):97-107. Epub 2015 Dec 13

Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.
http://www.ncbi.nlm.nih.gov/pubmed/26599973

Dinger J, Woods C, Brandt SD, Meyer MR, Maurer HH.

Toxicol Lett. 2016 Jan 22;241:82-94. Epub 2015 Nov 17.

Blood pressure changes after catheter-based renal denervation are related to reductions in total peripheral resistance.
http://www.ncbi.nlm.nih.gov/pubmed/26485463

Ewen S, Cremers B, Meyer MR, Donazzan L, Kindermann I, Ukena C, Helfer AG, Maurer HH, Laufs U, Grassi G, Böhm M, Mahfoud F.

J Hypertens. 2015 Dec;33(12):2519-25.

Low resolution and high resolution MS for studies on the metabolism and toxicological detection of the new psychoactive substance methoxypiperamide (MeOP).
http://www.ncbi.nlm.nih.gov/pubmed/26456786

Meyer MR, Holderbaum A, Kavanagh P, Maurer HH.

J Mass Spectrom. 2015 Oct;50(10):1163-74.

Prevalence and distribution patterns of amphetamine and methamphetamine consumption in a federal state in southwestern Germany using wastewater analysis.
http://www.ncbi.nlm.nih.gov/pubmed/26416694

Meyer MR, Vollerthun T, Hasselbach R.

Drug Alcohol Depend. 2015 Nov 1;156:311-4.

Orbitrap technology for comprehensive metabolite-based liquid chromatographic-high resolution-tandem mass spectrometric urine drug screening - Exemplified for cardiovascular drugs.
http://www.ncbi.nlm.nih.gov/pubmed/26388381

Helfer AG, Michely JA, Weber AA, Meyer MR, Maurer HH.

Anal Chim Acta. 2015 Sep 3;891:221-33.

First report on the pharmacokinetics of tramadol and O-desmethyltramadol in exhaled breath compared to plasma and oral fluid after a single oral dose.
http://www.ncbi.nlm.nih.gov/pubmed/26388171

Meyer MR, Rosenborg S, Stenberg M, Beck O.

Biochem Pharmacol. 2015 Dec 1;98(3):502-10.

Blood pressure reductions following catheter-based renal denervation are not related to improvements in adherence to antihypertensive drugs measured by urine/plasma toxicological analysis.
http://www.ncbi.nlm.nih.gov/pubmed/26306594

Ewen S, Meyer MR, Cremers B, Laufs U, Helfer AG, Linz D, Kindermann I, Ukena C, Burnier M, Wagenpfeil S, Maurer HH, Böhm M, Mahfoud F.

Clin Res Cardiol. 2015 Dec;104(12):1097-105.

Metabolism of the new psychoactive substances N,N-diallyltryptamine (DALT) and 5-methoxy-DALT and their detectability in urine by GC-MS, LC-MS (n) , and LC-HR-MS-MS.
http://www.ncbi.nlm.nih.gov/pubmed/26297461

Michely JA, Helfer AG, Brandt SD, Meyer MR, Maurer HH.

Anal Bioanal Chem. 2015 Oct;407(25):7831-42.

Toxicokinetics of lefetamine and derived diphenylethylamine designer drugs-Contribution of human cytochrome P450 isozymes to their main phase I metabolic steps.
http://www.ncbi.nlm.nih.gov/pubmed/26276083

Wink CS, Meyer GM, Meyer MR, Maurer HH.

Toxicol Lett. 2015 Nov 4;238(3):39-44.

Plasma and intracellular exposure to ganciclovir in adult renal transplant recipients: is there an association with haematological toxicity?
http://www.ncbi.nlm.nih.gov/pubmed/26538506

Billat PA, Woillard JB, Essig M, Sauvage FL, Picard N, Alain S, Neely M, Marquet P, Saint-Marcoux F.

J Antimicrob Chemother. 2016 Feb;71(2):484-9. Epub 2015 Nov 3.

Pharmacogenetic biomarkers predictive of the pharmacokinetics and pharmacodynamics of immunosuppressive drugs.
http://www.ncbi.nlm.nih.gov/pubmed/26469711

Picard N, Bergan S, Marquet P, van Gelder T, Wallemacq P, Hesselink DA, Haufroid V.

Ther Drug Monit. 2016 Apr;38 Suppl 1:S57-69. Epub 2015 Oct 13.

Analytical aspects of the implementation of biomarkers in clinical transplantation.
http://www.ncbi.nlm.nih.gov/pubmed/26418704

Shipkova M, López OM, Picard N, Noceti O, Sommerer C, Christians U, Wieland E.

Ther Drug Monit. 2016 Apr;38 Suppl 1:S80-92. Epub 2015 Jul 30.

Genetic variants in 6-mercaptopurine pathway as potential factors of hematological toxicity in acute lymphoblastic leukemia patients.
http://www.ncbi.nlm.nih.gov/pubmed/26237184

Hareedy MS, El Desoky ES, Woillard JB, Thabet RH, Ali AM, Marquet P, Picard N.

Pharmacogenomics. 2015;16(10):1119-34.

Genetic polymorphisms in the immune response: A focus on kidney transplantation.
http://www.ncbi.nlm.nih.gov/pubmed/26171975

Stojanova J, Pouché L, Picard N.

Clin Biochem. 2016 Mar;49(4-5):363-76. Epub 2015 Jul 11.

The Area Under the Concentration-Time Curve Is a Better Estimate for Vancomycin Exposure Than Trough Levels.
http://www.ncbi.nlm.nih.gov/pubmed/26274735

van Vessem DJ, Juffermans NP, Bouman CS, van Hest RM.

Crit Care Med. 2015 Sep;43(9):e401.

A cluster randomized trial for the implementation of an antibiotic checklist based on validated quality indicators: the AB-checklist.
http://www.ncbi.nlm.nih.gov/pubmed/25888180

van Daalen FV, Prins JM, Opmeer BC, Boermeester MA, Visser CE, van Hest RM, Hulscher ME, Geerlings SE.

BMC Infect Dis. 2015 Mar 19;15:134.

Is gentamicin affecting the neuromuscular system of critically ill patients?
http://www.ncbi.nlm.nih.gov/pubmed/25752304

Wieske L, van Hest RM, Witteveen E, Verhamme C, Schultz MJ, van Schaik IN, Horn J.

J Intensive Care Med. 2015 Apr;41(4):727-8.

A systematic review of prothrombin complex concentrate dosing strategies to reverse vitamin K antagonist therapy.
http://www.ncbi.nlm.nih.gov/pubmed/25480313

Khorsand N, Kooistra HA, van Hest RM, Veeger NJ, Meijer K.

Thromb Res. 2015 Jan;135(1):9-19.

Quantification of phosphatidylethanol 16:0/18:1, 18:1/18:1, and 16:0/16:0 in venous blood and venous and capillary dried blood spots from patients in alcohol withdrawal and control volunteers.
http://www.ncbi.nlm.nih.gov/pubmed/26597914

Kummer N, Ingels AS, Wille SM, Hanak C, Verbanck P, Lambert WE, Samyn N, Stove CP.

Anal Bioanal Chem. 2016 Jan;408(3):825-38. Epub 2015 Nov 23.

Detection of Benzodiazepines and z-Drugs in Hair Using an UHPLC-MS/MS Validated Method: Application to Workplace Drug Testing.
http://www.ncbi.nlm.nih.gov/pubmed/25627407

Ramírez Fernández Mdel M, Wille SM, di Fazio V, Kummer N, Hill V, Samyn N.

Ther Drug Monit. 2015 Oct;37(5):600-8

Applications of oral fluid and dried blood spots as a matrix for roadside drug testing.
Wille SM, Ingels A., Samyn N.

Bioanalysis. E-Book Chapter 7; New Sampling strategies in Toxicology and Therapeutic Drug Monitoring 2015

ISBN: 978-1-910420-09-6 (print)

2014

Dimethocaine, a synthetic cocaine analogue: studies on its in-vivo metabolism and its detectability in urine by means of a rat model and liquid chromatography-linear ion-trap (high-resolution) mass spectrometry.
http://www.ncbi.nlm.nih.gov/pubmed/24448968

Meyer MR, Lindauer C, Welter J, Maurer HH

Anal Bioanal Chem. 2014;406(7):1845-54

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