International Association of
Therapeutic Drug Monitoring and Clinical Toxicology
Fostering education, research and practice in TDM and CT

Pharmacometrics Committee

Brenda de Winter


Brenda de Winter
Rotterdam, the Netherlands


Contact Us
Scientific Committees
Pharmacometrics Committee

 Jean-Baptiste Woillard


Jean-Baptiste Woillard
Limoges, France

Background & Purpose of the Committee

Pharmacometrics (PM) has become progressively a key science in the drug development process and increasingly gaining importance in clinical study design and patient care, e.g. to inform dosing decisions within the framework of thereapeutic drug monitoring. It involves the development of (PB)PK or PK/PD or PK/PD/PG models that provide knowledge about the behaviour of a drug and how it can be optimally used. We believe pharmacometrics can help to describe or predict drug concentrations, their relationship with drug effects and clinical impacts. The application of PM models, e.g. using software tools, can also be very helpful to render personalized dose adjustments based on a patient’s individual parameters available in the clinical setting.

The aims of the pharmacometrics committee are:

  • Advance the field of "model-informed precision dosing" and its application in the clinical setting across different therapeutic areas.
  • Improve the design of clinical trials based on PM models using optimising study designs.
  • To develop and share educational tools about clinical pharmacometrics.
  • To have transversal activities with other committees of the IATDMCT.
  • To actively participate in joint meetings with other societies.

Activities Planned/Committee Initiatives Currently in Progress

The committee is planning to organize an interactive workshop for the meeting of 2021 in Rome to increase the use of PMx in the IATDMCT society. This meeting is targeted on people not involved in PK/PD modelling at this moment.

To achieve more efficient use of PK/PD data we will collaborate with other committees, and organize joint symposia for upcoming conferences.

Educational tools we are working on:

  • Article on graduation of PK/PD studies for systematic reviews
  • Updating articles about pharmacometric teaching

Past Years' Activities Held/Committee Initiatives

The committee is completely renewed at the congress in Iguazu and the period afterwards. The new members updated the text on the website and organized interesting meetings for the upcoming congress.

Publications, Scientific Contributions

We published the following articles in the IATDMCT COMPASS:

  • Dosing algorithms of tacrolimus in children (issue September 2019)
  • Workshop of Michael Neely in Argentina (issue March 2020)
  • The use of pharmacometrics in COVID-19 patients (issue September 2020)