International Association of
Therapeutic Drug Monitoring and Clinical Toxicology
Fostering education, research and practice in TDM and CT

Pharmacometrics Committee

Jean-Baptiste Woillard   Brenda de Winter   Contact Us





Contact Us

Jean-Baptiste Woillard
Limoges, France
  Brenda de Winter
Rotterdam, Netherlands
  Scientific Committee
Pharmacometrics Committee

Committee Purpose

  • To advance the field of "model-informed precision dosing" and its application in the clinical setting across different therapeutic areas.
  • To improve the design of clinical trials based on PM models using optimising study designs.
  • To develop and share educational tools about clinical pharmacometrics.
  • To have transversal activities with other committees of the IATDMCT.
  • To actively participate in joint meetings with other societies.

Pharmacometrics (PM) has become progressively a key science in the drug development process and increasingly gaining importance in clinical study design and patient care, e.g. to inform dosing decisions within the framework of thereapeutic drug monitoring. It involves the development of (PB)PK or PK/PD or PK/PD/PG models that provide knowledge about the behaviour of a drug and how it can be optimally used. We believe pharmacometrics can help to describe or predict drug concentrations, their relationship with drug effects and clinical impacts. The application of PM models, e.g. using software tools, can also be very helpful to render personalized dose adjustments based on a patient’s individual parameters available in the clinical setting.

Committee Initiatives & Activities

2021 The committee will organize the pre-congress symposium in the IATDMCT 2021 congress in Rome. This meeting is targeted on people not involved in PK/PD modelling at this moment.
To achieve more efficient use of PK/PD data we will collaborate with other committees, and organize joint symposia for upcoming conferences.
Roundtable in Rome: the use of machine learning approaches in clinical pharmacology.
2019 Educational tools we are working on:
  • Article on graduation of PK/PD studies for systematic reviews
  • Updating articles about pharmacometric teaching

Scientific Contributions

2021 Compass submissions:
  • Application of machine learning to estimate the immunosuppressant exposure: toward a new way to perform therapeutic drug monitoring (issue March 2021).
2020 Compass submissions:
    Workshop of Michael Neely in Argentina (issue March 2020).
  • The use of pharmacometrics in COVID-19 patients (issue September 2020).
2019 Compass submissions:
  • Dosing algorithms of tacrolimus in children (issue September 2019).

Additional Committee Resources


Minutes of Committee Meetings