International Association of
Therapeutic Drug Monitoring and Clinical Toxicology
Fostering education, research and practice in TDM and CT

Anti-Infective Drugs Committee

Debbie Marriott

Chair

Debbie Marriott
Sydney, Australia

contactus273x169

Contact Us
Scientific Committees
Anti-Infective Drugs Committee

Dario Cattaneo

Vice-Chair

Dario Cattaneo
Milan, Italy

Background & Purpose of the Committee

Over the past few years the field of TDM in infectious diseases has evolved. Based on this the scope of the Antifungal Drugs committee was expanded to Anti-Infective Drugs committee in 2011 (without antiretroviral drugs). During 2013, the HIV drugs committee proposed to have a joint Anti-Infective Drugs committee to preserve active members and broaden our interaction between colleagues. The proposal to join form a new larger Anti-Infective Drug committee (2013) was accepted with great enthusiasm. The previous experience of both committees will be beneficial, in particular the interplay with the multidisciplinary fields of Infectious Diseases.

Anti-Infective Drugs TDM is a challenging issue. The availability of LC (MS-MS) methods offers the potential to move from microbiological assays to physical-chemical procedures for the determination of these drugs in biological samples. It also provides multi-drug determination per run in a turnaround time that meets clinical relevance.

The main purposes of the AI committee are:

  • To promote the use of adequate analytical assays to quantify anti-infective drugs in biological matrices.
  • To develop and update guidelines for TDM based on current knowledge of target drug exposures and relevant biomarkers.
  • To encourage professionals to apply TDM in the field of infectious diseases and to report their results to increase the level of evidence for TDM.

Activities Planned/Committee Initiatives Currently in Progress

  • Regional Anti-Infectives TDM meeting – Singapore, November 2021 (to replace the event scheduled for November 4, 2020 and then canceled for the Covid-19 pandemic). This will be held immediately prior to the Asia-Pacific Conference on Clinical Microbiology and Infections, a well-respected conference attracting over 1000 delegates. It is anticipated that approximately 80 participants will attend. The ability to use speakers already invited to the APCCMI (Debbie Marriott, Jason Roberts) will reduce costs to IATDMCT. The Singapore Infectious Diseases Society has generously offered to provide their conference organizing facilities for our regional meeting.
  • The possibility of a future regional meeting in India is being explored.
  • The opportunity for affiliation with other societies is being actively examined.
  • New social media team (Indy Sandaradura, Danijela Kocic) will liaise with the Chair of the Communications Committee to increase content from the Anti-Infectives group.
  • Some of the members of the AI Committee are involved in the organization of the IATDMCT 2021 congress to be held in Rome (Sept. 19-21).
  • Many members of the AI Committee are currently working on consensus guidelines for the TDM of vancomycin.

Past Years' Activities Held/Committee Initiatives

  • Cattaneo D, Corona A, De Rosa FG, Gervasoni C, Kocic D, Marriott DJ. The management of anti-infective agents in intensive care units: the potential role of a 'fast' pharmacology. Expert Rev Clin Pharmacol. 2020 Apr;13(4):355-366.
  • Rao GG, Konicki R, Cattaneo D, Alffenaar JW, Marriott DJE, Neely M. Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics. Ther Drug Monit. 2020 Feb;42(1):83-92.
  • Cattaneo D, Baldelli S, Cozzi V, Clementi E, Marriott DJE, Gervasoni C. Impact of Therapeutic Drug Monitoring of Antiretroviral Drugs in Routine Clinical Management of People Living With HIV: A Narrative Review. Ther Drug Monit. 2020 Feb;42(1):64-74.
  • Kim HY, Märtson AG, Dreesen E, Spriet I, Wicha SG, McLachlan AJ, Alffenaar JW. Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review. Front Pharmacol. 2020 Jun 12;11:894.
  • Roberts JA, Joynt G, Lee A, Choi G, Bellomo R, Kanji S, Mudaliar MY, Peake SL, Stephens D, Taccone FS, Ulldemolins M, Valkonen MM, Agbeve J, Baptista JP, Bekos V, Boidin C, Brinkmann A, Buizen L, Castro P, Cole CL, Creteur J, De Waele JJ, Deans R, Eastwood GM, Escobar L, Gomersall C, Gresham R, Jamal JA, Kluge S, König C, Koulouras VP, Lassig-Smith M, Laterre PF, Lei K, Leung P, Lefrant JY, Llauradó-Serra M, Martin-Loeches I, Mat Nor MB, Ostermann M, Parker SL, Rello J, Roberts DM, Roberts MS, Richards B, Rodríguez A, Roehr AC, Roger C, Seoane L, Sinnollareddy M, Sousa E, Soy D, Spring A, Starr T, Thomas J, Turnidge J, Wallis SC, Williams T, Wittebole X, Zikou XT, Paul S, Lipman J. The effect of renal replacement therapy and antibiotic dose on antibiotic concentrations in critically ill patients: Data from the multinational SMARRT Study. Clin Infect Dis. 2020 Mar 9:ciaa224. doi: 10.1093/cid/ciaa224. Epub ahead of print.

Publications, Scientific Contributions

  • Members of the Anti-Infectives committee have over 100 publications in refereed journals in the last 12 months.
  • Presentations at over 30 national and international conferences.
  • 12 regular reviewers for peer-reviewed journals.

Recent Guidelines, Software Tools and Databases

  • Märtson AG, Sturkenboom MGG, Stojanova J, Cattaneo D, Hope W, Marriott D, Patanwala AE, Peloquin CA, Wicha SG, van der Werf TS, Tängdén T, Roberts JA, Neely MN, Alffenaar JC. How to design a study to evaluate therapeutic drug monitoring in infectious diseases? Clin Microbiol Infect. 2020 Mar 21:S1198-743X(20)30150-6.
  • Abdul-Aziz MH, Alffenaar JC, Bassetti M, Bracht H, Dimopoulos G, Marriott D, Neely MN, Paiva JA, Pea F, Sjovall F, Timsit JF, Udy AA, Wicha SG, Zeitlinger M, De Waele JJ, Roberts JA; Infection Section of European Society of Intensive Care Medicine (ESICM); Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID); Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT); Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC). Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper. Intensive Care Med. 2020 Jun;46(6):1127-1153.