International Association of
Therapeutic Drug Monitoring and Clinical Toxicology
Fostering education, research and practice in TDM and CT

Alternative Sampling Strategies Committee

Rafael Linden


Rafael Linden
Universidade Feevale, Brazil


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Scientific Committees
Alternative Sampling Strategies Committee

Jan-Willem Alffenaar


Jan-Willem Alffenaar
University of Sidney, Australia

Background & Purpose of the Committee

The committee brings scientists together who work in the field of alternative sampling / working with alternative samples. The aims are:

  • To promote the exchange of information via providing a platform for easy, informal exchange of information;
  • To enhance collaboration between groups working on related subjects via extending the professional network; and
  • To encourage discussion on the latest developments in the field.

Scientific Contributions

The committee had published a review manuscript entitled “Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Development and Validation of Dried Blood Spot–Based Methods for Therapeutic Drug Monitoring” in the Therapeutic Drug Monitoring journal (Ther Drug Monit. 2019 Aug;41(4):409-430). This work presents detailed information for the proper development and validation of DBS assays in the context of TDM.

As decided on the committee meeting held during the Foz do Iguaçu congress, another review manuscript was prepared by the committee members, headed by Lisa Delahaye and Chistophe Stove from the University of Ghent, focusing on alternative sampling devices to collect dried blood microsamples, other than classical DBS. This manuscript was recently published with the title “Alternative Sampling Devices to Collect Dried Blood Microsamples: State-of-the-Art” (Ther Drug Monit. 2021 Jun;43(3):310-321).

Additional Committee Resources

A free web-based application for evaluating spot quality in dried blood spots sampling was developed by the group of Jan-Willem Alffenaar at the University of Groningen. This app was described in the following publication: Performance of a web-based application measuring spot quality in dried blood spot sampling. Veenhof H, Koster RA, Brinkman R, Senturk E, Bakker SJL, Berger SP, Akkerman OW, Touw DJ, Alffenaar J. C.Clin Chem Lab Med. 2019 Nov 26;57(12):1846-1853.

Links to access the application are available below:

Minutes of Committee Meetings